There are a lot of products out there claiming to help fight the signs of aging. Wherever you look, there are claims of everlasting youth and longevity being shouted at you. It’s hard to know what’s real and what’s a lie.
There have been some promising studies in the field of anti-aging supplements that have shown some promising results.
Some supplements have shown remarkable effects on skin elasticity and other topical signs of aging. 
Many have shown not just to help the look of aging but also to slow down or reverse the aging process inside as well.
Now:
There is no all-in-one anti-aging supplement!
Some can reduce muscle loss, joint pain, heart health, and mental health, help with weight loss, and strengthen your bones. Others can help enhance vision, strengthen a weakened immune system, and enhance overall performance.
It’s important to understand a few reasons why these supplementation work and the science behind them. When you have a basic understanding of how they work, it’s harder to have the wool pulled over your eyes.
We looked into seven of the most well-researched supplementation to help with longevity and what makes them so effective. We take an in-depth look at the mechanisms and the results of many studies below.
Table of Contents
Best Anti-Aging Supplements to Slow Sign of Aging That May Actually Work (2023)
1. NAD SUPPLEMENTS Cell Rejuvenation – Best Longevity Supplement
As we age, the NAD+ produced in our bodies is dramatically reduced. It is thought that NAD+ reduction may be one of the biggest culprits of why people age at all.
In a Harvard Medical School study, scientists found that by increasing NAD+ in mice they could dramatically reverse the aging process. The oral administered high levels of NAD+ daily.
The result was that two-year-old mice looked and were genetically similar to mice only a few months old.
This same study on humans hasn’t yet been completed, but after the discovery of what NAD+ could be capable of, there have been numerous human clinical trials on NAD+.
These trials have shown some promising results for humans.
One of the ways NAD has been shown to increase NAD+ production in aging bodies is through its precursor NR.
When we take a nicotinamide riboside, it will naturally produce NAD+ and may aid in repairing our cells and keep our bodies younger and longer (Read more about NAD+ supplements here)
In a study, scientists discovered that giving nicotinamide riboside to elderly mice, it restored their organs’ ability to regenerate.
NR compounds are now available for sale as a supplement.
The leading brand is Tru Niagen which sells potent, powerful NR supplements.
Their patented product is used in other supplementation, and they lead the way in NR and NAD+ research today.
If you are looking for a trusted NR supplementation, Tru Niagen may be the best option and is currently the #1 anti-aging supplement on a market.
.
2. NMN Supplements – Best NAD Precursor
\Nicotinamide mononucleotide (NMN) is a molecule that is involved in several important biological processes in the body, including energy metabolism and DNA repair. Some researchers have suggested that NMN supplements may have the potential to improve health and extend lifespan by supporting these processes.
NMN supplements are typically taken as dietary supplements in the form of a capsule, powder, or liquid. They can be purchased online or at certain health food stores.
There is some evidence from animal studies that NMN supplements may have potential health benefits, such as improving insulin sensitivity and reducing inflammation. However, more research is needed to determine whether NMN supplements are safe and effective for humans.
It is important to note that NMN supplements are not regulated by the U.S. Food and Drug Administration (FDA) and the safety and effectiveness of these supplements have not been fully evaluated by the FDA. As with any dietary supplement, it is important to speak with a healthcare provider before starting to take NMN supplements.
3. COLLAGEN PEPTIDES – Best for Younger-Looking Skin?
What supplements to take to look younger?
It would be Collagen.
Collagen is a protein abundant in bones, muscles, tendons, and skin. Collagen works in your body as a buffer between bones. It helps with the elasticity of skin and muscles.
It is also essential for repairing and preserving connective tissues like ligaments and tendons.
As we age collagen production slows down in our bodies and as a result, we get degradation of our overall elasticity.
Collagen is one of the top overall AA supplementations when it comes to skin and bone health.
There have now been numerous studies that show that taking oral supplementation of collagen can increase skin elasticity, get to hold moisture and relieve joint pain.
It’s also used to help treat osteoarthritis. It is not a cream but a great skincare product nevertheless.
Taking collagen before and after aging begins can help treat internal and external problems related to aging.
There are very few known risks of taking collagen.
This is one of the best supplements for the skin and it is widely prescribed by doctors and dermatologists worldwide.
The best brand we have found for good, clean, and naturally sourced collagen is Perfect Keto Collagen.
.
Use LEANOP15 code & SAVE 15%
4. Resveratrol to Fight Aging
.
Resveratrol is the reason red wine was talked about so much in the news. It was recommended to keep your heart healthy you should have a glass of wine a night.
Out of all the compounds found in wine few are as well-researched and have shown as many promising results as resveratrol. 
Resveratrol works by activating and increasing sirtuin activity.
It has been shown to slow down and reverse the aging process. It can mimic the effect of a calorie restriction by decreasing insulin sensitivity, restoring cardiovascular health, and promoting autophagy. There have been numerous studies showing that resveratrol can help with heart health.
It has been shown to have capabilities including slowing down cognitive deterioration. Resveratrol has also been shown to help to reduce and minimize wrinkles.
A cup of wine only gives you a tiny dose of resveratrol. In fact, in the whole bottle of red wine, there is only 0.2 to 5.8 mg.
To get 500 mg of resveratrol, you would need to drink 40 bottles of wine. Some supplements offer a hefty dose of resveratrol without the overconsumption of wine. Thorne Research offers a good Resveratrol supplement called ResveraCel.
It includes a good dose of naturally sourced resveratrol as well as other healthy sirtuin-activating compounds found in red wine.
This pill also includes the Tru Niagens NR compound as well. It’s an excellent buy for all-around longevity supplements.
.
5. RAPAMYCIN as a Longevity Supplement
Rapamycin is a prescription drug used to treat people who receive a transplant or have stents put in their hearts.
Recently Rapamycin has been being looked at because of its ability to act as an inhibitor of mTOR.
Rapamycin is not a supplement but rather a yeast-derived antibiotic.
It has been shown to extend the lifespan of yeast, worms, flies, and middle-aged mice.
Rapamycin mimics the effects of calorie restriction, promoting autophagy, lowering insulin resistance, and reducing mTOR levels.
It has been shown to have a reversing or slowing down effect on many age-related diseases like heart disease, cancer, Alzheimer’s disease, and loss of eyesight.
This drug, while used on humans for other purposes, has not been tested for long-term use in helping with longevity. It is not known how dangerous it can be when taken for long periods.
Moreover, because this drug affects your blood glucose levels, it can cause a rapid decrease in blood sugar.
Do not take this medication unless prescribed by a doctor.
It is recommended that you test your blood sugar levels consistently while taking it.
6. METFORMIN
Metformin is another prescription medication that works on the AMPK pathway and may reduce mTOR levels. It is most commonly used to treat diabetes.
Lowering blood sugar levels, can mimic the effects of long-term fasting and help to reverse the symptoms of ingesting too many carbohydrates.
There has been some promising research (animal studies) into metformin in terms of longevity, but research into human trials is still needed.
This is another drug that needs to be closely supervised by a doctor as it can cause rapid decreases in blood sugar.
But there is a supplementation that may mimic the effects of these two prescription drugs. For a natural alternative, there’s Berberine.
It’s a quaternary ammonium salt that is produced by plants. It is thought to work similarly to metformin and can help safely regulate blood sugar.
It can decrease inflammation caused by excessive sugar consumption. It has been shown to work on the AMPK pathway to promote autophagy.
This supplementation doesn’t have many adverse reactions but shouldn’t be taken if someone is already taking blood sugar medication.
7. COENZYME Q10
Coenzyme CoQ10 is a well-known antioxidant compound; your body naturally produces it to help convert food into usable energy.
There has been some research that points to CoQ10 improving the elasticity of the skin, reducing wrinkles, and improving overall texture.
It may also help alleviate age-related issues such as oxidative stress brought on by a CoQ10 deficiency.
As we age, our bodies slow down their production of CoQ10.
By supplementing this coenzyme, it may be able to restore its ability to act as an antioxidant, reduce oxidative stress, and help with longevity.
8. CURCUMIN / TURMERIC
Turmeric is known around the world as a culinary spice. In some languages, it is called curcumin. Confusingly the anti-inflammatory substance inside turmeric has also been named curcumin.
Curcumin, the active substance in turmeric, has been shown to help prevent cancer and most importantly decrease inflammation. Many issues with the body come back to inflammation. Heart disease caused by plaque is caused when inflammation swells the arteries, and the body produces cholesterol to heal the rips and tears.
Joint pain, chronic fatigue, and muscle pain have all been linked to inflammation. Taking turmeric or refined curcumin, research has found that it can help keep down inflammatory responses in the body. The best curcumin supplement choice is Thorne Researches Meriva SF this curcumin offers a 29 times absorption rate than other pills. That is because the company has made this curcumin more bioavailable.
.
9. FISH OIL / KRILL OIL
Omega-3 fatty acids are essential for healthy aging, healthy living, and staying generally healthy. Whether the source is fish oil or krill oil, omega Omega-3 fatty acids can provide many beneficial effects.
They have been shown to ensure heart health, lower the risk of muscle deterioration, and prevent loss of vision.
Because of the way our body utilizes omega fatty acids, they are crucial to cognitive health.
Your body needs fatty acids to function. Ingesting enough omega-3 fatty acids has been shown to reduce the risk of cognitive decline and dementia. Many people have been found to lack this crucial fatty acid in their diet.
Taking a supplement can ensure healthy brain function as well as joints, muscles, and bones as we age.
Nordic Naturals Omega-3 Phospholipids is our recommendation for a good supplementation.
Phospholipids are designed to be more bioavailable, especially for people with the APOE4 gene.
Apolipoprotein E or the APOE gene is a gene involved in processing fat in the bloodstream.
If you have this gene, it is a risk factor for late-onset Alzheimer’s.
By taking bioavailable omega-3 supplements, you may be able to delay or negate the risk of cognitive failure & cognitive decline.
.
9. VITAMIN C
What vitamin is best for anti-aging?
It is Vitamin C. We all know that vitamin C can ward off colds or other viruses. It is one of the most potent antioxidants that has also been shown to improve skin texture and appearance.
Vitamin C, also known as ascorbic acid, is a natural way to stimulate collagen production.
Vitamin C is an essential, water-soluble vitamin that is found to reverse and repair sun-damaged skin or aging skin (protects the skin from sun damage or even skin cancer). It can also help reduce fine lines and wrinkles (anti-wrinkle effect).
Some beauty products are now packed full of vitamin C because of these amazing results, but it is most effective when ingested.
An excellent choice for a naturally sourced and non-GMO supplement would be Viva Naturals Premium Vitamin C with Bioflavonoids.
Bioflavonoids are other plant-derived compounds that have been shown to help metabolize and utilize vitamin C.’
Vitamin C can be considered one of the best vitamins.
Some other products/vitamins that some people believe also have effects are: green tea or green tea extract, vitamin E (protects cell membranes), amino acids such as creatine and arginine or L-arginine, stem cell supplements (no proof of working), telomere products to increase telomere length (no proof of working), Off-label use of hormones (estrogen and progesterone)
.
10. Crocin
Crocin from Kashmiri saffron (Crocus sativus) flowers is reported to have antipyretic, antitussive, and expectorant properties against cough.
Antiseptic properties have also been reported for this compound. Saffron is the predominant feature of the Indian platelet mix. It is also prominent in the vegetarian version of the mixed rice mix.
The nutritional value of saffron is 20 times that of the gram for gram. Saffron is an excellent source of flavonoids and phenolic compounds. Saffron contains potent anti-malarial, anti-ulcer, and anti-inflammatory properties.
The extract of crocus or crocus mandshurites is used to treat malaria in India and the Middle East. Saffron seed is used in the laboratory to remove nitrogen from the air. Saffron may help in the treatment of diabetes mellitus and high blood pressure.
It is an excellent source of beta-carotene, the precursor to vitamin A. Saffron consumption can also reduce the risk of some cancers. It contains a chemical compound crocetin, a natural flavonoid that has been shown to have anti-tumor.
11. Rhodiola For Health and Longevity
One of the easiest ways to get all the benefits of a healthy lifestyle is to get a healthy body. Whether you want to look and feel your best now, or you plan to age with a positive mind, the right supplement can help. Now, let’s get into the details and explore the benefits of Rhodiola Rosea, a supplement that may be effective in improving lifespan, longevity, and both energy and body chemistry. In fact, it has been reported to help regulate blood glucose levels, improve nerve and muscle function, improve metabolism, and increase bone density, and cognitive function.
Although it’s a relatively new supplement, with only a couple of decades of research behind it, it has earned quite a bit of notoriety. So much so that it’s now available in a nearly endless variety of concentrated forms and at a variety of prices.
So, what exactly is Rhodiola?
Well, it’s a natural plant product that comes from a relatively unknown area in Siberia. In fact, the area of origin is the Rhodope Mountains in Bulgaria. Interestingly enough, it is also one of the oldest recorded sources of medicinal plants on Earth.
Over the years, Rhodiola has been used as a treatment for more than 25 medical ailments, with varying degrees of success. Some of these medical uses are chronic pain, respiratory disorders, gastrointestinal disorders, circulation issues, urinary tract infections, and depression. Interestingly, some of these diseases and ailments are comparable to those which are often found in the elderly, including osteoporosis, cardiovascular disease, memory loss, depression, and cognitive issues.
12. Vitamin E
Defends against: Environmental skin breakage and dullness
Study shows that vitamin E has anti-inflammatory properties. It is important in cell turnover and skin regeneration, the method in which dead skin cells swamp off and radiant, healthier cells take their place. Vitamin E also protects the skin from wrinkle-forming UV radiation and environmental destruction. Also, the purpose of vitamin e is to treat infections but can act as a weak digestive aid as well. Vitamin e acts as a weak antiseptic to kill a wide variety of bacteria. Start with 1000 mg a day (1000 mg is one milligram). That’s easily achievable in most foods. At 10,000 mg, you can probably feel the difference, so you can increase it to 20,000 mg. For daily needs, supplement with 500 mg.
Recommended dose: 200 IU per day
What Vitamins Should I Take to Look Younger?
There are two main types of vitamins, either naturally occurring (there are none naturally occurring in a plant) or synthetic. Natural vitamins are nothing new. We’ve all heard the terms “vitamins A, B, C, and D,” but these are the types of vitamins we actually want to think about when we’re thinking about how to look younger. These vitamins don’t just have an outward effect on how we look — they’ve also got direct benefits for our health. But the really cool thing is that these nutrients have at least some “outside” health benefits, too. For example, having a good intake of vitamins A and D can reduce the risk of diabetes and osteoporosis. Vitamin E, which is also an antioxidant, can decrease the risk of macular degeneration. While the human body naturally produces a number of these vitamins, we do need to supplement them every day all time.
Here are some recommendations from vitamin expert Dr. Jason Johnson. Vitamins A and D. We’re all familiar with vitamin A. This is a fat-soluble vitamin that, after it’s broken down by your body, is used as an antioxidant. Vitamin A is involved in many different processes in your body. To support the functions of the immune system, vitamin A is essential for the absorption of fat-soluble nutrients like carotenoids, which give plants their bright colors. Vitamin A deficiency can lead to dry eyes, night blindness, macular degeneration, and macular edema. Vitamin D is another fat-soluble vitamin that helps the body absorb fat-soluble nutrients like zinc, vitamin E, and calcium. It also supports the absorption of calcium, especially if you’ve been taking a calcium supplement.
The Sirtuins: Longevity Gene Activation
Sirtuins are part of a family of proteins that has a role in regulating cell health. There are seven sirtuins in the human body. They play a crucial role in the aging process.
As we get older nicotinamide adenine dinucleotide or NAD decreases in our body.
NAD+ is a coenzyme that is found in all living cells. Sirtuins function through the usage of NAD+.
As this coenzyme diminishes so too does our body’s ability to heal itself.
The cellular health of your body depends on the function of your sirtuins. Some of its main causes include accumulated cellular damage caused by reactive molecules known as free radicals and the shortening of telomeres.
Your sirtuins need NAD+ to be active. The less nicotinamide adenine dinucleotide you have, the less your cells can heal themselves.
The primary role of sirtuins is to remove acetyl groups from proteins.
This helps the DNA sequence properly. When it isn’t active, that’s when our bodies begin to break down.
Since their discovery 20 years ago scientists have been studying sirtuins nonstop.
They have dubbed them “the longevity genes” because of their function in healing DNA.
By increasing the NAD+ in your body and the sirtuins, you can add longevity to your cells.
The research into these two pathways has led to some surprising and promising results.
The combination of active Sirtuins and high levels of NAD+ has been shown to have the same positive effects of calorie restriction and fasting.
Including regulating blood sugar, lowering your insulin sensitivity, and helping to eliminate cancer cells.
They are also shown to slow down or even reverse the aging process.
By taking the precursor to NAD+ called NR, you can increase your NAD+ even as you age.
Supplements can also help increase sirtuins in your body and through the combination of the two they can work to help us stay young naturally.
Anti-Aging Pathways Explained
In the last few decades, scientists have figured out precisely what regulates our cell health.
Through a series of pathways, our cells maintain their function and stay robust and fully functioning.
When these pathways are turned off, bodies start to break down by taking a supplement that can activate these pathways and slow down or reverse the aging process.
We have covered Sirtuins and NAD+ above, but there are other players in this game.
mTOR is another protein that plays a key role in the longevity of cells and ultimately life.
mTOR links with other proteins and becomes two different complexes; mTOR complex 1 and mTOR complex 2.
These two complexes regulate different cellular processes.
mTOR is sugar-fed and is currently under scrutiny for having a direct link to sugar diseases like insulin sensitivity, diabetes, and Alzheimer’s.
What has been found is that too much mTOR is a bad thing but too little is also bad. When there is too much mTOR, it can turn off autophagy.
Autophagy is your body’s way of recycling bad cells and cleaning up the body. Too little mTOR means your body can’t grow new cells properly. The key to harmony is finding the proper amount of mTOR for optimal cell function.
AMPK or 5′ AMP-activated protein kinase is also involved in processing carbohydrates.
A healthy level of AMPK in the right issues can help decrease insulin, improves insulin sensitivity, and promote autophagy.
AMPK is involved in many of the anti-aging pathways including regulating mTOR and aiding sirtuins and NAD+.
AMPK is found in all living cells and is essential to energy balance & energy production. It detects the level of energy and signals the body when it is too high or low.
So we need to increase Sirtuin activity through NAD+, regulate levels of mTOR, and promote AMPK activity. How is this all done?
Well, one promising way is through calorie restriction and fasting.
If we restrict sugar intake for a while, our body can reset its pathways and fix the levels of these complexes.
Another way is through natural supplements that encourage the correct levels of each of these complexes.
Potential Benefits
Some supplementation promotes AMPK, NAD+, and Sirtuins as well as regulates mTOR in our bodies.
There are choices that can control blood sugar levels and help support natural cell recycling and autophagy.
There are also anti-aging herbal supplements that have been shown to decrease inflammation and degeneration of joints, skin, muscles, and cardiovascular function.
By taking supplements that have been shown to encourage the correct amount of cell regulation.
Then we can encourage anti-aging and restore cell health.
Many of the most promising supplements help inhibit the dangerous effects of too much sugar in our bodies. Some help attack and safely eliminate free radicals in our bodies.
Through supplements, you can gain some antiaging benefits, restore healthy cell activity, and decrease your risk of heart disease, cancer, free radicals elimination, cognitive disorders, and other deteriorating diseases.
What Vitamins or Herbs Can Keep You Looking Younger As You Age?
Even if you are on your way out of your teens, it’s still normal to wish you could turn back the clock a bit. And unfortunately, there’s no quick fix, but there are a number of natural remedies you can use that will help in keeping those wrinkles and fine lines at bay, while making your skin look smooth and luminous.
Pulse Opinion turned to some experts to find out more about these popular remedies to keep you looking and feeling younger, while also addressing any possible side effects. Panthenol. There is no cure for getting older,” says Dr Paul van Deursen, a skincare expert who was until recently employed as an expert adviser by L’Oréal. “But having a certain level of anxiety about your appearance might be the best way to prevent you from aging,” he adds. One way he recommends combatting your fear of aging is by taking a vitamin supplement. “Drinking pure oxygen before a sunbed session for example might actually make you look younger.
What is the Best Procedure to Look Younger?
Most people are fooled into thinking that wrinkles come with age. This is simply not true. Everyone gets some wrinkles from time to time, but if you want to stop them from coming, you can be sure of one thing; it’s going to be down to diet and exercise. Nutrition and healthy living can help you look and feel younger than your years. It is well known that if you don’t exercise regularly, you will not get any results. However, if you don’t eat properly then the two do not go together.
Exercising is much more than just going for a run. It is becoming aware of what you’re putting into your body. A lack of exercise is just as bad as putting in excessive time at the gym. In fact, it’s often worse. Over-exercising does you more harm than good. Nutrition is equally as important. It doesn’t have to be a radical change, just simpler than before. Start by adding some lean protein to your meals, like fish or meat. Use greens to increase your vegetables and try to cut down on sugar. Also, if you do decide to eat oily fish or meat, make sure that it is not fried in a lot of trans fats, which are a real trigger for belly fat.
How Can I Stop Anti-Aging Naturally?
I’m 36 years old. Over the last year, I’ve been drinking collagen-infused, pH-balanced aloe juice, eating maca and goji berries, and, oh yeah, exercising almost daily, all of which have led me to feel great! So why are some of my wrinkles deepening? After feeling smug about the plump lines on my forehead and around my eyes last fall, I hit a skincare roadblock last month. Looking at my new pearlescent skin in the mirror, I asked myself a troubling question: Is it even possible to reverse the effects of time? The question’s answer, unfortunately, was “no.”
Restoring your glow to that of a 20-year-old can take years of natural products like chemical exfoliants, rosewater toners, and high-intensity exfoliation (a.k.a. manual-brush massages). There is a slight caveat, though: There are over-the-counter anti-aging products on the market that work quickly. Below, are some of my favorite finds that will help you reach your next Botox peak before you know it. This overnight microneedling pen uses potent microcurrent technology to enhance fine lines and wrinkles. Pop in a napkin or a cotton ball, and pop in a moisturizer like Laura Mercier Total Eye Cream, which contains powerful peptides to soothe your skin while it heals.
What Vitamin Keeps You Looking Younger?
Vitamin C is a crucial nutrient that plays a significant role in maintaining a youthful appearance. It is renowned for its antioxidant properties, which help protect the skin from oxidative stress and damage caused by free radicals. Vitamin C is essential for collagen synthesis, a protein that provides structural support to the skin, giving it strength and elasticity. Collagen production naturally declines with age, leading to the appearance of wrinkles and sagging skin.
By promoting collagen synthesis, vitamin C can help reduce the signs of aging and maintain a more youthful complexion. Additionally, vitamin C possesses skin-brightening properties, as it inhibits melanin production and helps fade dark spots and hyperpigmentation, contributing to a more even skin tone. Regular intake of vitamin C through diet or topical application of vitamin C-containing skincare products can help keep the skin looking younger and more vibrant.
In addition to vitamin C, another vitamin that contributes to a more youthful appearance is vitamin A, specifically in the form of retinol. Retinol has been widely recognized for its remarkable ability to improve skin texture and appearance. It is a key ingredient found in many anti-aging creams due to its effectiveness in reducing wrinkles, hyperpigmentation, and acne.
Retinol works by stimulating collagen production and promoting cell turnover, which helps to smooth out fine lines and wrinkles, giving the skin a more youthful and plump appearance. It also aids in fading hyperpigmentation by inhibiting the production of melanin, the pigment responsible for dark spots and uneven skin tone.
Moreover, retinol is beneficial for individuals struggling with acne. It helps unclog pores, reduces inflammation, and regulates oil production, resulting in fewer breakouts and a clearer complexion.
It is worth noting that retinol, especially in higher concentrations, may cause skin sensitivity and irritation. Therefore, it is recommended to start with lower concentrations and gradually increase usage to allow the skin to adjust. Additionally, it is important to use sunscreen when incorporating retinol into a skincare routine, as retinol can increase skin sensitivity to the sun.
Final Thoughts
There are a lot of pills on the market that claims to be the #1 anti-aging supplement.
It can be hard to navigate the barrage of information and advertisements out there.
There are however some actual potentially effective supplements to take. We hope this article helped to shed some light on this subject.
If you want to start taking supplements, we recommend CoQ10, collagen, and Tru Niagen or ResveraCel made by Thorne Research.
Together they will provide you with the ability to stay young naturally and aid in cellular rejuvenation. Also, make sure to get enough sleep (7-9 hours is recommended)
**These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.